Laura roach design 3603/29/2023 ![]() ![]() Liposomes are attractive carriers since they protect biological molecules from degradation while improving their cellular uptake. The process was later demonstrated in vivo by K. ![]() The process of introducing functional nucleic acids into cultured cells by using positively charged liposomes was first described by Philip Felgner et al. 13, 238-252), there has been a sustained interest and effort in developing lipid-based carrier systems for the delivery of biologically active agents. Since the first description of liposomes in 1965 by Bangham (J. Such compositions are reported to contain liposomes. Viral vectors can be used to transfer genes efficiently into some cell types, but they generally cannot be used to introduce chemically synthesized molecules into cells.Īn alternative approach is to use delivery compositions incorporating cationic lipids which interact with a biologically active agent at one part and interact with a membrane system at another part (for a review, see Felgner, 1990, Advanced Drug Delivery Reviews, 5, 162-187 and Felgner, 1993, J. The most well-studied approaches for improving the transport of foreign nucleic acids into cells involve the use of viral vectors or cationic lipids. For these reasons, compositions that can stabilize and deliver nucleic acid-based agents into cells are of particular interest. The development of RNA interference, RNAi therapy, RNA drugs, antisense therapy and gene therapy, among others, has increased the need for an effective means of introducing active nucleic acid agents into cells. In general, nucleic acids are stable for only a limited duration in cells or plasma. One class of biologically active agents that is particularly difficult to deliver to cells is a biotherapeutic (including nucleosides, nucleotides, polynucleotides, nucleic acids and derivatives, such as RNAi agents). Lipid carriers, biodegradable polymers and various conjugate systems can be used to improve delivery of biologically active agents to cells. ![]() One solution to this problem is to utilize specific carrier molecules which are allowed selective entry into the cell. These restrictions can result in the need to use much higher concentrations of biologically active agents than is desirable to achieve a result, which increases the risk of toxic effects and side effects. In particular, the trafficking of many biologically active agents into living cells is highly restricted by the complex membrane systems of the cells. The delivery of biologically active agents (including therapeutically relevant compounds) to subjects is often hindered by difficulties in the compounds reaching the target cell or tissue. This invention also relates to processes for making such compounds and compositions, and to methods and uses of such compounds and compositions, e.g., to deliver biologically active agents, such as RNAi agents, to cells and tissues. This invention relates to cationic lipid compounds and to compositions comprising such compounds. ![]() The applicant for LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS patent is This invention was filed in the category of Was filed with the USPTO on Friday, March 7, 2014. The LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS patent Patent Application Number is a unique ID to identify the LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS mark in USPTO. – by the United States Patent and Trademark Office (USPTO). The LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS patent was assigned a LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS - Patent Information By Jeremy Lee BARYZA ![]()
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